Set is the mind-set or expectation one brings to the experience, and setting is the environment in which it takes place. Compared with other drugs, psychedelics seldom affect people the same way twice, because they tend to magnify whatever’s already going on both inside and outside one’s head. — *location: 225* ^ref-57753 --- Carl Jung once wrote that it is not the young but people in middle age who need to have an “experience of the numinous” to help them negotiate the second half of their lives. — *location: 235* ^ref-20620 --- LSD appears to disable such conventionalized, shorthand modes of perception and, by doing so, restores a childlike immediacy, and sense of wonder, to our experience of reality, as if we were seeing everything for the first time. (Leaves!) — *location: 263* ^ref-53454 --- Serious research into psychedelics had been more or less purged from the university fifty years ago, soon after Timothy Leary’s Harvard Psilocybin Project crashed and burned in 1963. — *location: 269* ^ref-54841 --- The study demonstrated that a high dose of psilocybin could be used to safely and reliably “occasion” a mystical experience—typically described as the dissolution of one’s ego followed by a sense of merging with nature or the universe. — *location: 284* ^ref-11312 --- What is striking about this whole line of clinical research is the premise that it is not the pharmacological effect of the drug itself but the kind of mental experience it occasions—involving the temporary dissolution of one’s ego—that may be the key to changing one’s mind. — *location: 296* ^ref-14235 --- My default perspective is that of the philosophical materialist, who believes that matter is the fundamental substance of the world and the physical laws it obeys should be able to explain everything that happens. I start from the assumption that nature is all that there is and gravitate toward scientific explanations of phenomena. That said, I’m also sensitive to the limitations of the scientific-materialist perspective and believe that nature (including the human mind) still holds deep mysteries toward which science can sometimes seem arrogant and unjustifiably dismissive. — *location: 306* ^ref-39773 --- There is not a culture on earth (well, one*) that doesn’t make use of certain plants to change the contents of the mind, whether as a matter of healing, habit, or spiritual practice. That such a curious and seemingly maladaptive desire should exist alongside our desires for nourishment and beauty and sex—all of which make much more obvious evolutionary sense—cried out for an explanation. — *location: 318* ^ref-53104 --- But it’s important to distinguish what can happen when these drugs are used in uncontrolled situations, without attention to set and setting, from what happens under clinical conditions, after careful screening and under supervision. Since the revival of sanctioned psychedelic research beginning in the 1990s, nearly a thousand volunteers have been dosed, and not a single serious adverse event has been reported. — *location: 341* ^ref-52181 --- over time, we tend to optimize and conventionalize our responses to whatever life brings. Each of us develops our shorthand ways of slotting and processing everyday experiences and solving problems, and while this is no doubt adaptive—it helps us get the job done with a minimum of fuss—eventually it becomes rote. It dulls us. The muscles of attention atrophy. — *location: 349* ^ref-43736 --- If you need to be reminded how completely mental habit blinds us to experience, just take a trip to an unfamiliar country. Suddenly you wake up! And the algorithms of everyday life all but start over, as if from scratch. — *location: 354* ^ref-39751 --- The efficiencies of the adult mind, useful as they are, blind us to the present moment. — *location: 356* ^ref-38779 --- One of the things that commends travel, art, nature, work, and certain drugs to us is the way these experiences, at their best, block every mental path forward and back, immersing us in the flow of a present that is literally wonderful—wonder being the by-product of precisely the kind of unencumbered first sight, or virginal noticing, to which the adult brain has closed itself. (It’s so inefficient!) Alas, most of the time I inhabit a near-future tense, my psychic thermostat set to a low simmer of anticipation and, too often, worry. The good thing is I’m seldom surprised. The bad thing is I’m seldom surprised. — *location: 360* ^ref-16361 --- as a staunch materialist, and as an adult of a certain age, I had pretty much closed my accounts with reality. Perhaps this had been premature. Well, here was an invitation to reopen them. — *location: 379* ^ref-16621 --- Despite the 1960s trappings, the term “psychedelic,” coined in 1956, is etymologically accurate. Drawn from the Greek, it means simply “mind manifesting,” which is precisely what these extraordinary molecules hold the power to do. — *location: 402* ^ref-33603 --- “Mysticism,” he likes to say, “is the antidote to fundamentalism.” — *location: 634* ^ref-61669 >Rick Doblin --- William James gave a name to this conviction: the noetic quality. People feel they have been let in on a deep secret of the universe, and they cannot be shaken from that conviction. As James wrote, “Dreams cannot stand this test.” — *location: 700* ^ref-31436 --- “There is so much authority that comes out of the primary mystical experience that it can be threatening to existing hierarchical structures.” — *location: 954* ^ref-23784 --- Richard Boothby did much the same thing, converting his insight about letting go into a kind of ethic: During my session this art of relaxation itself became the basis of an immense revelation, as it suddenly appeared to me that something in the spirit of this relaxation, something in the achievement of a perfect, trusting and loving openness of spirit, is the very essence and purpose of life. Our task in life consists precisely in a form of letting go of fear and expectations, an attempt to purely give oneself to the impact of the present. — *location: 1145* ^ref-8800 --- On the back was a quotation from William Blake that, it occurred to me later, neatly aligned the way of the scientist with that of the mystic: “The true method of knowledge is experiment.” — *location: 1283* ^ref-61414 --- Scientists at the University of British Columbia (UBC) injected fir trees with radioactive carbon isotopes, then followed the spread of the isotopes through the forest community using a variety of sensing methods, including a Geiger counter. Within a few days, stores of the radioactive carbon had been routed from tree to tree. Every tree in a plot thirty meters square was connected to the network; the oldest trees functioned as hubs, some with as many as forty-seven connections. The diagram of the forest network resembled a map of the Internet. In what is surely a tip of the hat to Stamets, a paper by one of the UBC scientists dubbed it the “wood-wide web.” — *location: 8977* ^ref-60301 --- What strikes me about both Stamets and many of the so-called Romantic scientists (like Humboldt and Goethe, Joseph Banks, Erasmus Darwin, and I would include Thoreau) is how very much more alive nature seems in their hands than it would soon become in the cooler hands of the professionals. These more specialized scientists (a word that wasn’t coined until 1834) gradually moved science indoors and increasingly gazed at nature through devices that allowed them to observe it at scales invisible to the human eye. These moves subtly changed the object of study—indeed, made it more of an object. Instead of seeing nature as a collection of discrete objects, the Romantic scientists—and I include Stamets in their number—saw a densely tangled web of subjects, each acting on the other in the great dance that would come to be called coevolution. “Everything,” Humboldt said, “is interaction and reciprocal.” They could see this dance of subjectivities because they cultivated the plant’s-eye view, the animal’s-eye view, the microbe’s-eye view, and the fungus’s-eye view—perspectives that depend as much on imagination as observation. — *location: 1918* ^ref-684 --- IN THE MID-1950S, Bill Wilson, the cofounder of Alcoholics Anonymous, learned about Osmond and Hoffer’s work with alcoholics. The idea that a drug could occasion a life-changing spiritual experience was not exactly news to Bill W., as he was known in the fellowship. He credited his own sobriety to a mystical experience he had on belladonna, a plant-derived alkaloid with hallucinogenic properties that was administered to him at Towns Hospital in Manhattan in 1934. Few members of AA realize that the whole idea of a spiritual awakening leading one to surrender to a “higher power”—a cornerstone of Alcoholics Anonymous—can be traced to a psychedelic drug trip. — *location: 2254* ^ref-36039 --- On occasion, the LSD produced genuine insight, as it did for Brand himself one chilly afternoon in the spring of 1966. Bored, he went up onto the roof of his building in North Beach and took a hundred micrograms of acid—Fadiman’s creativity dose. As he looked toward downtown while wrapped in a blanket, it appeared that the streets lined with buildings were not quite parallel. This must be due to the curvature of Earth, Brand decided. It occurred to him that when we think of Earth as flat, as we usually do, we assume it is infinite, and we treat its resources that way. “The relationship to infinity is to use it up,” he thought, “but a round earth was a finite spaceship you had to manage carefully.” At least that’s how it appeared to him that afternoon, “from three stories and one hundred mikes up.” It would change everything if he could convey this to people! But how? He flashed on the space program and wondered, “Why haven’t we seen a picture of the earth from space? I become fixed on this, on how to get this photo that would revolutionize our understanding of our place in the universe. I know, I’ll make a button! But what should it say? ‘Let’s have a photo of the earth from space.’ No, it needs to be a question, and maybe a little paranoid—draw on that American resource. ‘Why haven’t we seen a photograph of the whole earth yet?’” Brand came down from his roof and launched a campaign that eventually reached the halls of Congress and NASA. Who knows if it was the direct result of Brand’s campaign, but two years later, in 1968, the Apollo astronauts turned their cameras around and gave us the first photograph of Earth from the moon, and Stewart Brand gave us the first edition of the Whole Earth Catalog. Did everything change? The case could be made that it had. — *location: 2705* ^ref-39290 --- Drawing on their extensive fieldwork, however, Leary did do some original work theorizing the idea of “set” and “setting,” deploying the words in this context for the first time in the literature. These useful terms, if not the concepts they denote—for which Al Hubbard deserves most of the credit—may well represent Leary’s most enduring contribution to psychedelic science. — *location: 2786* ^ref-59769 --- (It is one of the many paradoxes of psychedelics that these drugs can sponsor an ego-dissolving experience that in some people quickly leads to massive ego inflation. Having been let in on a great secret of the universe, the recipient of this knowledge is bound to feel special, chosen for great things.) — *location: 2838* ^ref-14671 --- Huxley and Hubbard and Osmond shared Leary’s sense of historical mission, but they had a very different idea of how best to fulfill it. The three were inclined to a more supply-side kind of spiritualism—first you must turn on the elite, and then let the new consciousness filter down to the masses, who might not be ready to absorb such a shattering experience all at once. Their unspoken model was the Eleusinian mysteries, in which the Greek elite gathered in secret to ingest the sacred kykeon and share a night of revelation. But Leary and Ginsberg, both firmly in the American grain, were determined to democratize the visionary experience, make transcendence available to everyone now. — *location: 2840* ^ref-47598 --- Now the story was out, and very soon Timothy Leary, always happy to supply a reporter with a delectably outrageous quote, was famous. He delivered a particularly choice one after the university forced him to put his supply of Sandoz psilocybin pills under the control of Health Services: “Psychedelic drugs cause panic and temporary insanity in people who have not taken them.” — *location: 2881* ^ref-57862 --- the extent that Ken Kesey and his Pranksters helped shape the new zeitgeist, a case can be made that the cultural upheaval we call the 1960s began with a CIA mind-control experiment gone awry. — *location: 3025* ^ref-43353 --- Temporarily freed from the tyranny of the ego, with its maddeningly reflexive reactions and its pinched conception of one’s self-interest, we get to experience an extreme version of Keats’s “negative capability”—the ability to exist amid doubts and mysteries without reflexively reaching for certainty. To cultivate this mode of consciousness, with its exceptional degree of selflessness (literally!), requires us to transcend our subjectivity or—it comes to the same thing—widen its circle so far that it takes in, besides ourselves, other people and, beyond that, all of nature. — *location: 3932* ^ref-7664 --- When I think back on this part of the experience, I’ve occasionally wondered if this enduring awareness might have been the “Mind at Large” that Aldous Huxley described during his mescaline trip in 1953. Huxley never quite defined what he meant by the term—except to speak of “the totality of the awareness belonging to Mind at Large”—but he seems to be describing a universal, shareable form of consciousness unbounded by any single brain. Others have called it cosmic consciousness, the Oversoul, or Universal Mind. — *location: 3835* ^ref-26020 --- Only afterward did I wonder if this was what the mystics call the mysterium tremendum—the blinding unendurable mystery (whether of God or some other Ultimate or Absolute) before which humans tremble in awe. Huxley described it as the fear “of being overwhelmed, of disintegrating under a pressure of reality greater than a mind, accustomed to living most of the time in a cosy world of symbols, could possibly bear.” — *location: 4022* ^ref-49838 --- Before I drew the smoke into my lungs, Rocío had asked me, as she asks everyone who meets the toad, to search the experience for a “peace offering”—some idea or resolution I could bring back and put to good use in my life. Mine, I decided, had to do with this question of being and what I took to be its opposite term, “doing.” I meditated on this duality, which came to seem momentous, and concluded that I was too much occupied with the latter term in my life and not enough with the former. True, one had to favor doing in order to get anything done, but wasn’t there also a great virtue and psychic benefit in simply being? In contemplation rather than action? I decided I needed to practice being with stillness, being with other people as I find them (imperfect), and being with my own unimproved self. To savor whatever is at this very moment, without trying to change it or even describe it. (Huxley struggled with the same aspiration during his mescaline journey: “If one always saw like this, one would never want to do anything else.”) Even now, borne along on this pleasant contemplative stream, I had to resist the urge to drag myself onto shore and tell Rocío about my big breakthrough. No! I had to remind myself: just be with it. — *location: 4060* ^ref-53339 --- But the ego, that inner neurotic who insists on running the mental show, is wily and doesn’t relinquish its power without a struggle. Deeming itself indispensable, it will battle against its diminishment, whether in advance or in the middle of the journey. I suspect that’s exactly what mine was up to all through the sleepless nights that preceded each of my trips, striving to convince me that I was risking everything, when really all I was putting at risk was its sovereignty. — *location: 4176* ^ref-44498 --- When Huxley speaks of the mind’s “reducing valve”—the faculty that eliminates as much of the world from our conscious awareness as it lets in—he is talking about the ego. — *location: 4179* ^ref-37432 --- So perhaps spiritual experience is simply what happens in the space that opens up in the mind when “all mean egotism vanishes.” Wonders (and terrors) we’re ordinarily defended against flow into our awareness; the far ends of the sensory spectrum, which are normally invisible to us, our senses can suddenly admit. While the ego sleeps, the mind plays, proposing unexpected patterns of thought and new rays of relation. The gulf between self and world, that no-man’s-land which in ordinary hours the ego so vigilantly patrols, closes down, allowing us to feel less separate and more connected, “part and particle” of some larger entity. Whether we call that entity Nature, the Mind at Large, or God hardly matters. But it seems to be in the crucible of that merging that death loses some of its sting. — *location: 4192* ^ref-38975 --- (In an often-cited paper titled “A Wandering Mind Is an Unhappy Mind,” psychologists identified a strong correlation between unhappiness and time spent in mind wandering, a principal activity of the default mode network.) — *location: 4383* ^ref-14667 --- Shortly after Carhart-Harris published his results in a 2012 paper in PNAS (“Neural Correlates of the Psychedelic State as Determined by fMRI Studies with Psilocybin”*), Judson Brewer, a researcher at Yale* who was using fMRI to study the brains of experienced meditators, noticed that his scans and Robin’s looked remarkably alike. The transcendence of self reported by expert meditators showed up on fMRIs as a quieting of the default mode network. It appears that when activity in the default mode network falls off precipitously, the ego temporarily vanishes, and the usual boundaries we experience between self and world, subject and object, all melt away. — *location: 4392* ^ref-28831 --- The psychedelic experience of “non-duality” suggests that consciousness survives the disappearance of the self, that it is not so indispensable as we—and it—like to think. Carhart-Harris suspects that the loss of a clear distinction between subject and object might help explain another feature of the mystical experience: the fact that the insights it sponsors are felt to be objectively true—revealed truths rather than plain old insights. It could be that in order to judge an insight as merely subjective, one person’s opinion, you must first have a sense of subjectivity. Which is precisely what the mystic on psychedelics has lost. — *location: 4400* ^ref-30253 --- Another trippy thought experiment is to try to imagine the world as it appears to a creature with an entirely different sensory apparatus and way of life. You quickly realize there is no single reality out there waiting to be faithfully and comprehensively transcribed. — *location: 4449* ^ref-5895 --- “The Entropic Brain: A Theory of Conscious States Informed by Neuroimaging Research with Psychedelic Drugs,” published in Frontiers in Human Neuroscience in 2014. Here, Carhart-Harris attempts to lay out his grand synthesis of psychoanalysis and cognitive brain science. The question at its heart is, do we pay a price for the achievement of order and selfhood in the adult human mind? The paper concludes that we do. While suppressing entropy (in this context, a synonym for uncertainty) in the brain “serves to promote realism, foresight, careful reflection and an ability to recognize and overcome wishful and paranoid fantasies,” at the same time this achievement tends to “constrain cognition” and exert “a limiting or narrowing influence on consciousness.” — *location: 4483* ^ref-33677 --- “It’s not just that one system drops away,” he says, “but that an older system reemerges.” That older system is primary consciousness, a mode of thinking in which the ego temporarily loses its dominion and the unconscious, now unregulated, “is brought into an observable space.” This, for Carhart-Harris, is the heuristic value of psychedelics to the study of the mind, though he sees therapeutic value as well. — *location: 4521* ^ref-20226 --- “Distinct networks became less distinct under the drug,” Carhart-Harris and his colleagues wrote, “implying that they communicate more openly,” with other brain networks. “The brain operates with greater flexibility and interconnectedness under hallucinogens.” — *location: 4551* ^ref-29808 --- There are several ways this temporary rewiring of the brain may affect mental experience. When the memory and emotion centers are allowed to communicate directly with the visual processing centers, it’s possible our wishes and fears, prejudices and emotions, begin to inform what we see—a hallmark of primary consciousness and a recipe for magical thinking. Likewise, the establishment of new linkages across brain systems can give rise to synesthesia, as when sense information gets cross-wired so that colors become sounds or sounds become tactile. Or the new links give rise to hallucination, as when the contents of my memory transformed my visual perception of Mary into María Sabina, or the image of my face in the mirror into a vision of my grandfather. The forming of still other kinds of novel connections could manifest in mental experience as a new idea, a fresh perspective, a creative insight, or the ascribing of new meanings to familiar things—or any number of the bizarre mental phenomena people on psychedelics report. The increase in entropy allows a thousand mental states to bloom, many of them bizarre and senseless, but some number of them revelatory, imaginative, and, at least potentially, transformative. — *location: 4563* ^ref-46974 --- In The Philosophical Baby, Gopnik draws a useful distinction between the “spotlight consciousness” of adults and the “lantern consciousness” of young children. The first mode gives adults the ability to narrowly focus attention on a goal. (In his own remarks, Carhart-Harris called this “ego consciousness” or “consciousness with a point.”) In the second mode—lantern consciousness—attention is more widely diffused, allowing the child to take in information from virtually anywhere in her field of awareness, which is quite wide, wider than that of most adults. — *location: 4654* ^ref-51751 --- “We have the longest childhood of any species,” Gopnik says. “This extended period of learning and exploration is what’s distinctive about us. I think of childhood as the R&D stage of the species, concerned exclusively with learning and exploring. We adults are production and marketing.” Later I asked her if she meant to say that children perform R&D for the individual, not the species, but in fact she meant exactly what she said. “Each generation of children confronts a new environment,” she explained, “and their brains are particularly good at learning and thriving in that environment. Think of the children of immigrants, or four-year-olds confronted with an iPhone. Children don’t invent these new tools, they don’t create the new environment, but in every generation they build the kind of brain that can best thrive in it. Childhood is the species’ ways of injecting noise into the system of cultural evolution.” — *location: 4685* ^ref-43938 --- “So much of human suffering stems from having this self that needs to be psychologically defended at all costs. We’re trapped in a story that sees ourselves as independent, isolated agents acting in the world. But that self is an illusion. It can be a useful illusion, when you’re swinging through the trees or escaping from a cheetah or trying to do your taxes. But at the systems level, there is no truth to it. You can take any number of more accurate perspectives: that we’re a swarm of genes, vehicles for passing on DNA; that we’re social creatures through and through, unable to survive alone; that we’re organisms in an ecosystem, linked together on this planet floating in the middle of nowhere. Wherever you look, you see that the level of interconnectedness is truly amazing, and yet we insist on thinking of ourselves as individual agents.” Albert Einstein called the modern human’s sense of separateness “a kind of optical delusion of his consciousness.”* — *location: 5247* ^ref-43403 --- “Do you see the world as a prison or a playground?” is the key question Matt Johnson takes away from the rat park experiment. If addiction represents a radical narrowing of one’s perspective and behavior and emotional repertoire, the psychedelic journey has the potential to reverse that constriction, open people up to the possibility of change by disrupting and enriching their interior environment. “People come out of these experiences seeing the world a little more like a playground.” — *location: 5331* ^ref-60192 --- In particular, the changes in activity and connectivity in the default mode network on psychedelics suggest it may be possible to link the felt experience of certain types of mental suffering with something observable—and alterable—in the brain. If the default mode network does what neuroscientists think it does, then an intervention that targets that network has the potential to help relieve several forms of mental illness, including the handful of disorders psychedelic researchers have trialed so far. — *location: 5519* ^ref-20902 --- Another type of mental activity that neuroimaging has located in the DMN (and specifically in the posterior cingulate cortex) is the work performed by the so-called autobiographical or experiential self: the mental operation responsible for the narratives that link our first person to the world, and so help define us. “This is who I am.” “I don’t deserve to be loved.” “I’m the kind of person without the willpower to break this addiction.” Getting overly attached to these narratives, taking them as fixed truths about ourselves rather than as stories subject to revision, contributes mightily to addiction, depression, and anxiety. Psychedelic therapy seems to weaken the grip of these narratives, perhaps by temporarily disintegrating the parts of the default mode network where they operate. — *location: 5539* ^ref-26536 --- In a college commencement address he delivered three years before his suicide, David Foster Wallace asked his audience to “think of the old cliché about ‘the mind being an excellent servant but a terrible master.’ This, like many clichés, so lame and unexciting on the surface, actually expresses a great and terrible truth,” he said. “It is not the least bit coincidental that adults who commit suicide with firearms almost always shoot themselves in the head. They shoot the terrible master.” — *location: 5552* ^ref-21309 --- Whether the most magnificent of these stories represent a regression to magical thinking, as Freud believed, or access to transpersonal realms such as the “Mind at Large,” as Huxley believed, is itself a matter of interpretation. Who can say for certain? — *location: 5568* ^ref-57092 --- The usual antonym for the word “spiritual” is “material.” That at least is what I believed when I began this inquiry—that the whole issue with spirituality turned on a question of metaphysics. Now I’m inclined to think a much better and certainly more useful antonym for “spiritual” might be “egotistical.” — *location: 5572* ^ref-2915 --- Buddhists believe that attachment is at the root of all forms of mental suffering; if the neuroscience is right, a lot of these attachments have their mooring in the PCC, where they are nurtured and sustained. Brewer thinks that by diminishing its activity, whether by means of meditation or psychedelics, we can learn “to be with our thoughts and cravings without getting caught up in them.” Achieving such a detachment from our thoughts, feelings, and desires is what Buddhism (along with several other wisdom traditions) teaches is the surest path out of human suffering. — *location: 5598* ^ref-9280 >Posterior cyngulate cortex --- The posterior cingulate cortex is a centrally located node within the default mode network involved in self-referential mental processes. Situated in the middle of the brain, it links the prefrontal cortex—site of our executive function, where we plan and exercise will—with the centers of memory and emotion in the hippocampus. The PCC is believed to be the locus of the experiential or narrative self; it appears to generate the narratives that link what happens to us to our abiding sense of who we are. — *location: 5588* ^ref-34230 --- Institutions generally like to mediate the individual’s access to authority of whatever kind—whether medical or spiritual—whereas the psychedelic experience offers something akin to direct revelation, making it inherently antinomian. And yet some cultures have successfully devised ritual forms to contain and harness the Dionysian energies of psychedelics; think of the Eleusinian mysteries of ancient Greece or the shamanic ceremonies surrounding peyote or ayahuasca in the Americas today. — *location: 5752* ^ref-52830 --- This, I think, is the great value of exploring non-ordinary states of consciousness: the light they reflect back on the ordinary ones, which no longer seem quite so transparent or so ordinary. To realize, as William James concluded, that normal waking consciousness is but one of many potential forms of consciousness—ways of perceiving or constructing the world—separated from it by merely “the filmiest of screens,” is to recognize that our account of reality, whether inward or outward, is incomplete at best. — *location: 5787* ^ref-52976 ---